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Mahasuar R et al. – Hormonal side effects of antidepressants are infrequent, and galactorrhea is seldom mentioned among tricyclic antidepressant (TCA) and selective serotonin reuptake inhibitor (SSRI)–related side effects. Antidepressants can directly stimulate postsynaptic 5–HT receptors in the hypothalamus or indirectly inhibit the tuberoinfundibular dopaminergic neurons through 5–HT, which may increase prolactin levels and later cause galactorrhea.

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