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Nadler Y et al. – High Grb7 defines a subset of breast cancer patients with decreased survival, indicating that Grb7 might be a valuable prognostic marker and drug target. Coexpression with HER2/neu indicates that cotargeting these molecules might be an effective approach for treating HER2/neu–positive breast cancers. Future studies using Grb7–targeting agents should include assessment of Grb7 levels.

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