Ob/Gyn Medical News about premature ovarian failure

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Longer CAG repeat length in the androgen receptor gene is associated with premature ovarian failure
Human Reproduction, 08/24/09

Modi D et al. – The observation suggests that the CAG repeat length is increased in women with POF as compared with controls, and may be pathogenic for POF, at least in a subset of Indian women.

Exclusive Author Commentary
Deepak Modi, 08/25/09

Androgen receptors have been recently specualted to have a role in ovarain physiology and mice without androgen receptors have a POF like phenotype. The CAG repeat in the exon 1 of human androgen receptor is a determiant of its functionality. Longer CAG repeats lesser the activity, shoter repeats means high activity. Our analysis showed that the CAG repeat in exon 1 of androgen receptor is increased in POF cases. We belive that this extended repeats might reduce androgen receptor activity leading to POF in atleast some of the cases.

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Hormone replacement therapy and successful pregnancy in a patient with premature ovarian failure
Gynecological Endocrinology, 11/16/09 Relevance Score: 83%

In vitro fertilisation (IVF) with donor eggs in post-menopausal women: are there differences in pregnancy outcomes in women with premature ovarian failure (POF) compared with women with physiological age-related menopause
Journal of Assisted Reproduction and Genetics, 10/26/09 Relevance Score: 80%

Array Comparative Genomic Hybridization Profiling Analysis Reveals Deoxyribonucleic Acid Copy Number Variations Associated with Premature Ovarian Failure
Journal of Clinical Endocrinology and Metabolism, 10/29/09 Relevance Score: 79%

Estrogen receptor gene polymorphisms in patients with idiopathic premature ovarian failure
Human Reproduction, 10/28/09 Relevance Score: 79%

FOXL2 mutations lead to different ovarian phenotypes in BPES patients: Case Report
Human Reproduction, 10/13/09 Relevance Score: 79%