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Gains in Body Fat and Vasomotor Symptom Reporting Over the Menopausal Transition
American Journal of Epidemiology, 08/13/09
Thurston RC et al. – Body fat gains are associated with greater hot flash reporting during the menopausal transition.
Methods- Measures of bioelectrical impedance for body fat, reproductive hormones, and reported vasomotor symptoms were assessed annually over 4 years from 2002 to 2006 among 1,659 women aged 47–59 years participating in the Study of Women's Health Across the Nation.
- Body fat change was examined in relation to vasomotor symptoms by using generalized estimating equations.
- Body fat gains were associated with greater odds of reporting hot flashes in models adjusted for age, site, race/ethnicity, education, smoking, parity, anxiety, and menopausal status.
- Findings persisted controlling for estradiol, the free estradiol index, or follicle–stimulating hormone concentrations.
- The relations between body fat changes and night sweats were not statistically significant.
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