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Martens MG et al. – In the study, the frequency of total and subclinical HSV–2 shedding was greater than reported in earlier studies involving subjects with a history of symptomatic genital recurrences. The authors study is the first to demonstrate a significant reduction in viral shedding with valacyclovir 1 g daily compared to placebo in a population of subjects newly diagnosed with HSV–2 infection.

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