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Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators
Psychoneuroendocrinology, 07/27/09
Andreen L et al. – Progesterone and progestagens induce negative mood, most probably via their GABAA receptor active metabolites. In postmenopausal women treated with progesterone ,there is a bimodal association between serum allopregnanolone concentration and adverse mood, resembling an inverted U–shaped curve. In humans, the maximal effective concentration of allopregnanolone for producing negative mood is within the range of physiological luteal phase serum concentrations.
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Today in Menopausal Medicine...keeping you current
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Optimal Timing of Breast MRI Examinations for Premenopausal Women Who Do Not Have a Normal Menstrual Cycle
American Journal of Roentgenology, 11/30/09
Urinary incontinence and waist circumference in older women
Age and Aging, 11/20/09
Effects of menopausal hormone therapy on hemostatic parameters, blood pressure, and body weight: Open-label comparison of randomized treatment with estradiol plus drospirenone versus estradiol plus norethisterone acetate
European Journal of Obstetrics & Gynecology and Reproductive Biology , 11/20/09
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