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See Latest ArticlesThe antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells
Anti-Cancer Drugs, 07/24/09
Yde CW et al. – To investigate this putative mechanism, the authors applied biophysical techniques to simple model membranes in the form of unilamellar liposomes of well–defined composition and found that chlorpromazine interacts strongly with lipid bilayers of different composition leading to increased permeability. This implies that chlorpromazine can change influx properties of membranes hence suggesting that chlorpromazine may be a promising chemosensitizing compound for enhancing the cytotoxic effect of tamoxifen.
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