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HOXA11 Promotes Fibroblast Proliferation and Regulates p53 in Uterosacral Ligaments
Reproductive Sciences, 07/08/09
Connell KA et al. - Expression of HOXA11 represses expression of p53, suggesting a mechanism by which HOXA11 regulates of the morphology and integrity of the USLs. A better understanding of the influence of these genes on the homeostasis of the ECM and interactions with each other may prove beneficial in defining the underlying etiologies of the development of POP and aid in the development of new treatment options for women with this disorder.
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