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Increased 5alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome
Journal of Clinical Endocrinology and Metabolism, 07/01/09
Stewart PM et al. - PCOS is associated with enhanced androgen and cortisol metabolite excretion and increased 5alpha-reductase activity that cannot be explained by obesity alone. Increased adrenal corticosteroid production represents an important pathogenic pathway in PCOS.
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