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Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib
Investigational New Drugs, 06/30/09
Bruning A et al. - The combination of nelfinavir with sorafenib induced mitochondrial membrane potential disruption and resulted in an improved activity of nelfinavir on ovarian cancer cells. Thus, a combination of these two investigational anti-cancer drugs could be of interest especially because of their unique mechanism of apoptosis induction even in otherwise chemo-resistant human cancer cells.
Today in Basic Science/Genetics...keeping you current
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Maternal Effects for Preterm Birth: A Genetic Epidemiologic Study of 630,000 Families
American Journal of Epidemiology, 10/26/09
Adipose tissue expandability and the early origins of PCOS
Trends in Endocrinology and Metabolism, 10/16/09
Fluctuations in anti-factor Xa levels with therapeutic enoxaparin anticoagulation in pregnancy
Journal of Perinatology, 10/16/09
Today in Gynecologic Oncology...keeping you current
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Cost-Effectiveness of Human Papillomavirus Vaccination and Cervical Cancer Screening in Women Older Than 30 Years in the United States
Annals of Internal Medicine, 10/20/09
Ovarian cancer screening and early detection
Women's Health, 11/03/09
Current status of maintenance therapy for advanced ovarian cancer
International Journal of Women's Health, 11/03/09
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