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Aging attenuates the pituitary response to gonadotropin releasing hormone
Journal of Clinical Endocrinology and Metabolism, 07/01/09

Hall JE et al. - In studies that isolated the pituitary from endogenous GnRH stimulation, aging attenuated the LH and FSH responses to exogenous GnRH in postmenopausal women. These studies indicate that the pituitary plays a role in the decline in gonadotropin levels with aging, further supporting the potential contribution of age-associated changes in both hypothalamic and pituitary function to reproductive senescence.

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