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See Latest ArticlesHistone Acetylated Control of Fibroblast Growth Factor Receptor 2 Intron 2 Polymorphisms and Isoform Splicing in Breast Cancer
Molecular Endocrinology, 06/05/09
Zhu X et al. - The findings highlight the potential role of histone acetylation in modulating access to selected polymorphic sites within intron 2 as well as downstream splicing sites in generating variable FGFR2 levels and isoforms in breast cancer.
Shereen Ezzat, 06/05/09
| Single nucleotide polymorphisms are of increasingly recognized significance. How they impact endogenous gene expression and function, however, remains largely unknown. In this study, we demonstrate that intronic polymorphisms associated with increased breast cancer risk alter DNA accessibility to promote transcription factor binding. Such interactions serve to modulate gene expression beyond the role of classical promoters. |
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