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PDE8A Genetic Variation, Polycystic Ovary Syndrome and Androgen Levels in Women
Molecular Human Reproduction, 06/01/09

Strauss JF et al. - The more common coding sequence SNP (N401S), and the promoter SNPs were not associated with PCOS in transmission/disequilibrium test (TDT)-based analysis, nor where they associated with total testosterone or hydroepiandrosterone sulphate (DHEAS) levels. These findings exclude a significant role for PDE8A as a PCOS candidate gene and a major determinant of androgen levels in women.

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