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Estradiol-17-beta inhibits GnRH-induced Ca2+ in gonadotropes to regulate negative feedback on LH release
Endocrinology, 06/05/09
Iqbal J et al. - Inhibition of the GnRH-induced increase in [Ca2+]i in gonadotropes by E2 is a likely mechanism for the negative feedback effect of E2 on LH secretion involving a rapid non-genomic effect of E2. Activation of the MAPK pathway by E2 may be the mechanism for the time-delayed positive feedback effect on LH secretion at the level of the gonadotrope.
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Defining hyperandrogenism in polycystic ovary syndrome: measurement of testosterone and androstenedione by liquid chromatography-tandem mass spectrometry and analysis by receiver operator characteristic (ROC) plots
European Journal of Endocrinology, 12/15/09
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