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See Latest ArticlesExpression of endoglin (CD105) in cervical cancer
British Journal of Cancer, 04/17/09
Zijlmans HJ et al. - In a trial to investigate the role of endoglin (CD105), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor-A (VEGF-A) in cervical cancer, it was concluded that clinically the number of CD105-positive vessels associated with the number of lymph node metastasis. The presence of CD105-positive vessels within the epithelial cell clusters associated with poor disease-free survival (DFS).
Methods- The number was measured and the location of both newly formed (CD105-positive) and the overall number of (CD31-positive) blood vessels, and bFGF and VEGF-A expression were determined using immunohistochemistry in 30 cervical carcinoma specimens.
- Vascular endothelial growth factor-A mRNA expression was determined using RNA-in situ hybridisation.
- CD105- and CD31-positive vessels and bFGF- and VEGF-A-positive cells were predominantly present in the stroma.
- Presence of CD105- and CD31-positive vessels in the stroma did neither correlate with the number of VEGF-A-positive cells nor the number of bFGF-positive cells.
- The number of CD105- and CD31-positive vessels was associated with expression of VEGF-A mRNA in the epithelial cell clusters.
- Presence of CD105-positive and CD31-positive vessels was associated with the expression of αvβ6.
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