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Qu F et al. - After 12 weeks of treatment, HAMD scores in both groups decreased significantly with no significant difference between the group. The levels of FSH decreased significantly and the level of E2 increased significantly in both groups, and they changed more in the control group. No side-effect of treatment was reported in either group during treatment. The Chinese medicinal formula GNL showed promise in relieving perimenopausal depression and merits further study.

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