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Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial
Breast Cancer Research and Treatment, 10/16/08
Hervik J et al. – Acupuncture effectively relieves hot flashes both day and night in operative breast cancer pts treated with Tamoxifen; the treatment effect is associated with general health improvement measured with the validated Kupperman index
Methods- Prospective, controlled trial of the efficacy of acupuncture in 59 breast cancer pts with hot flashes due to anti-estrogen medication
- Review of pts after breast cancer surgery and adjuvant estrogen-antagonist treatment (tamoxifen)
- Randomization to either 10 wks of traditional Chinese acupuncture or sham acupuncture (SA)
- Mean number of hot flashes at day and night noted before treatment, during treatment, and 12 wks post-treatment
- Validated health score (Kupperman index) at baseline, at treatment end, and at 12 wks post-treatment
- For acupuncture pts during treatment, mean number of hot flashes day and night was significantly reduced by 50% and ~60%, respectively from baseline; further reduced by 30% both day and night during next 12 wks
- For SA pts during treatment, day hot flashes were significantly reduced by 25%; this reversed during the following 12 wks; no reduction in night hot flashes
- Kupperman index: reduced by 44% from baseline to treatment end and largely maintained 12 wks after treatment in acupuncture pts; no such changes noted for SA pts
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