Ob/Gyn Medical News about early stage breast cancer;pre-diagnosis BMI,post-daignosis weight change, and prognosis

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials

3. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

4. 2008 Exclusive Survey—Earnings: Good news for primary care income

5. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer
Cancer Causes and Control, 09/05/08

Caan BJ et al. – Obesity before breast cancer diagnosis is associated with increased risk of recurrence and poorer survival; weight gain after diagnosis did not confer additional risk; body weight pre-diagnosis may be strongest predictor of an adverse breast cancer prognosis

Methods

Study of the association between body mass index (BMI) at diagnosis, weight change post-diagnosis, and breast cancer prognosis in a prospective cohort study of 1,692 breast cancer survivors
Calculation of weight change and BMI based on questionnaires for pre-diagnosis weight, weight at study entry, and height

Results

At 7-yr follow-up, 207 recurrences, 99 deaths due to breast cancer, and 162 deaths due to any cause
Obesity 1 yr pre-diagnosis was associated with an increased risk of death from any cause and possibly increased risk of death from breast cancer
Weight gain up to 4 yrs after diagnosis was not associated with an increased risk of recurrence or death from any cause; moderate weight loss (5–10%) did not decrease risk of these outcomes
Women with larger weight losses (≥10%) between pre-diagnosis and study entry had an increased risk of recurrence and death due to any cause vs weight-stable pts
This elevated risk was more pronounced among women obese before diagnosis (BMI ≥30 kg/m2) or with ER- or PR- tumors

<< Previous
Comparison of cancer registry and clinical data as predictors for...

Next >>
Activity of chemotherapy in mucinous ovarian cancer with a...

Conservative surgery with and without radiotherapy in elderly patients with early-stage breast cancer: A prospective randomised multicentre trial
The Breast, 11/16/09 Relevance Score: 90%

Reliable data on 5- and 10-year survival provide accurate estimates of 15-year survival in estrogen receptor-positive early-stage breast cancer
Breast Cancer Research and Treatment, 10/13/09 Relevance Score: 90%

Original contribution: association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
JAMA, 10/07/09 Relevance Score: 90%

Serum calcium levels are elevated among women with untreated postmenopausal breast cancer
Cancer Causes and Control, 11/03/09 Relevance Score: 89%

Rethinking Screening for Breast Cancer and Prostate Cancer
JAMA, 10/23/09 Relevance Score: 89%