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Pretreatment tumor diameter/volume and pelvic lymph node status assessed by magnetic resonance imaging for uterine cervical carcinoma treated with concurrent chemotherapy and radiotherapy
Journal of Obstetrics and Gynaecology Research, 09/05/08

Kim HJ et al. - Tumor volume and enlarged pelvic lymph nodes seen on pretreatment MRI were significant prognostic factors for pts with invasive cervical carcinoma treated with concurrent chemotherapy and radiotherapy

Methods

Study of the prognostic value of tumor diameter and volume and pelvic lymph node status assessed by MRI in pts with uterine cervical carcinoma treated with concurrent chemotherapy and radiotherapy
Review of 98 pts diagnosed with stage IB to IIIB cervical carcinoma Tumor diameter evaluated in T2-weighted imageTumor volume calculated by equation (volume = width × length × height × π/6) as ellipsoid approximation
Univariate and multivariate analyses for prognostic factors for overall survival (OS), disease-free survival (DFS), pelvic control (PC) and distant metastasis-free survival (DMFS)

Results

5-yr rates: OS 59.8%; DFS 57.3%; PC 67.9%; DMFS 78.8%
In univariate analyses, large MRI tumor diameter (≥4 cm), large tumor volume (≥30 mL), pelvic enlarged pelvic lymph nodes, large clinical diameter (≥4 cm) and FIGO stage had a statistically significant unfavorable effect on OS and DFS
In multivariate analyses, large tumor volume affected OS, DFS, PC, and DMFS; enlarged pelvic lymph nodes also affected OS