Ob/Gyn

Your Article Summary

See Latest Articles

Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas
International Journal of Cancer, 08/20/08

Partheen K et al. - In a trial to assess the gene and protein expressions for 7 potential biomarkers, to determine if it is possible to use them as prognostic factors, it was determined that the 4 biomarkers CLU, ITGB3, PRAME and CAPG may be used as prognostic factors for pts with stage III serous ovarian adenocarcinomas

• Genes selected from a previous microarray analysis, CLU, ITGB3, TACC1, MUC5B, CAPG, PRAME and TROAP, were analyzed in 19 of the tumors with quantitative real-time polymerase chain reaction
• Protein expressions of CLU, ITGB3, PRAME and CAPG were analyzed in 43 of the tumors with western blot for semiquantitative analysis
• Immunohistochemistry was used to localize expression of the proteins in tumor samples

• CLU and ITGB3 were more expressed in tumors from survivors and PRAME and CAPG were more expressed in tumors from deceased pts
• None of the other 3 genes were significantly differently expressed
• The mRNA and protein expressions correlated and all 4 proteins were significantly differently expressed

Today in Gynecologic Oncology...keeping you current

Receive free subspecialty "5-minute updates" via email

A Prospective Study of Dairy Intake and Risk of Uterine Leiomyomata
American Journal of Epidemiology, 12/03/09

Multiple 18F-FDG, PET-CT for Postoperative Monitoring of Breast Cancer Patients
Acta Radiologica, 12/02/09

Assessment of the sentinel lymph node in patients with invasive squamous carcinoma of the vulva
Acta Obstetricia et Gynecologica Scandinavica, 12/02/09

 See all of Gynecologic Oncology