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See Latest ArticlesAugmented HER-2–Specific immunity during treatment with trastuzumab and chemotherapy
Clinical Cancer Research, 09/07/07
Taylor, C., et al. - In a study to assess whether immune sensitization to HER-2/neu tumor antigen occurs during treatment with the anti-HER-2/neu monoclonal antibody trastuzumab, it was found that humoral immune sensitization occurs during treatment with chemotherapy and trastuzumab
Methods- 27 patients treated with trastuzumab and chemotherapy were assessed for the induction of HER-2/neu–specific immunity
- Sera and peripheral blood mononuclear cells obtained before and after trastuzumab therapy were compared for presence of anti-HER-2/neu endogenous Ig antibodies and HER-2/neu–specific CD4 responses by ELISA and enzyme-linked immunospot, respectively
- Anti-HER-2/neu antibodies were detectable in 29% of patients before trastuzumab treatment and 56% of patients during trastuzumab treatment
- Anti-HER-2/neu humoral responses significantly increased during therapy and were not associated with development of an anti-idiotypic response
- In 10 evaluable individuals, 6 showed augmented HER-2/neu–specific CD4 T-cell responses during therapy
- Of the 22 individuals treated for metastatic disease, patients showing objective clinical responses exhibited more frequent and larger treatment-associated anti-HER-2/neu humoral responses
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