The Influence of Pubertal Timing on Bone Mass Acquisition: A Predetermined Trajectory Detectable Five Years before Menarche Chevalley T et al. - In prepubertal girls who will experience later menarche a deficit in aBMD can already be observed before the onset of pubertal maturation, with no further accumulated deficit until PBM compared to girls with earlier menarche. It suggests that shorter estrogen exposure from prepuberty to PBM is not the main factor for increased osteoporosis risk associated with later menarche. Rather common genetic determinants of low bone mass and later puberty could be involved. [more...]
