Genetic Screening Reveals an Essential Role of p27kip1 in Restriction of Breast Cancer Progression
Yuan, Y., et al. - The genetic changes and mechanisms underlying the progression of estrogen-dependent breast cancers to estrogen-independent, antiestrogen-resistant, and metastatic breast cancers are unclear despite being a major problem in endocrine therapy. To identify genes responsible for this progression, we carried out a genetic screening by an enhanced retroviral mutagen (ERM)–mediated random mutagenesis in the estrogen-dependent T47D breast cancer cells [more...]
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