Top hpv Articles in Ob/Gyn

The prevalence of human papillomavirus type 58 in Chinese patients with cervical carcinoma and its influence on survival
Clinical Oncology, 11/12/2009

Shah W et al. – No effect was seen of either treatment protocols or HPV type on survival, except for a slightly high survival in HPV 58 single-infected patients, which was statistically non-significant. Methods 120 patients with ... of HPV and HPV type-specific infections with polymerase chain reaction Experimental data co-analysed with follow-up data to evaluate prognosis and survival in relation to HPV infection and treatment Results All samples found to be positive for HPV; 32.40% (95 ... 42.09) of samples were HPV 16 single positive, 16.67% (95% confidence interval 10.19–25.06) were HPV 58 single positive, 34.26% (95% confidence interval 25.4–44.01) were HPV 16/58 double positive and 16.67% (95% confidence interval 10.19–25.06) were positive for other HPV types 5-year ... HPV 58 single positive, HPV 16 single positive HPV 16/58 double positive, and other HPV types, respectively (P=0.18), irrespective of the treatment modalities Univariate Cox regression analysis results showed that compared with HPV 16 single positive group, RR of death was high in HPV 16/58 ... double positive group (hazard ratio 1.81, 95% confidence interval 0.71–4.60) and the other HPV types group (hazard ratio 2.09, 95% confidence interval 0.73–5.96), was lower in HPV 58 single positive group (hazard ratio 0.53, 95% confidence interval 0.11–2.56), not statistically significant [more...]

FDA Approves Gardasil to Prevent Genital Warts in Males. Agency Also Approves Bivalent HPV Vaccine for Girls, Young Women
American Family Physician, 10/27/2009

The FDA has expanded its approval of Merck & Co. Inc.'s quadrivalent human papillomavirus, or HPV, vaccine, which is marketed as Gardasil, to include use of the vaccine to prevent ... up to a bivalent HPV vaccine for girls and young women. During clinical trials in more than 4,000 males, Gardasil was nearly 90 percent effective in preventing genital warts caused by infection with HPV types 6 and 11. Gardasil was approved in 2006 for use in girls and young women ages 9–26 years ... caused by HPV types 16 and 18; genital warts caused by HPV types 6 and 11; and precancerous or dysplastic lesions caused by HPV types 6, 11, 16, and 18. Merck's vaccine soon will have competition from GlaxoSmithKline Biologicals, or GSK. The FDA approved GSK's bivalent HPV vaccine, Cervarix, on Oct ... the prevention of cervical cancer and precancerous lesions caused by HPV types 16 and 18 in girls and women ages 10–25. [more...]

Immunosuppressive cytokine Interleukin-10 (IL-10) is up-regulated in high-grade CIN but not associated with high-risk human papillomavirus (HPV) at baseline, outcomes of HR-HPV infections or incident CIN in the LAMS cohort
Virchows Archiv, 11/17/2009

AuthorLastNameFI et al. – IL-10 over-expression (along with HR-HPV) was one of the independent covariates of CIN2/3. This immunosuppressive ... by HR-HPV. Methods Baseline cervical biopsies from 225 women of LAMS study sub-cohort analyzed for IL-10 expression using immunohistochemistry, to assess its associations with CIN grade, and high-risk HPV (HR-HPV) at baseline, as well as in predicting outcomes of HR-HPV ... HR-HPV and several known covariates of IL-10 expression Up-regulation not related to HR-HPV detection, and showed no relationship to HR-HPV viral loads Using longitudinal predictive indicators (SE, SP, PPV, NPV), IL-10 expression of no value in predicting (1) outcomes of HR-HPV [more...]

Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
New England Journal of Medicine, 11/10/2009

Kenter GG et al. – Clinical responses in women with HPV-16–positive, grade 3 vulvar intraepithelial neoplasia can be achieved by vaccination with a synthetic long-peptide vaccine against the HPV-16 oncoproteins E6 and E7 ... be correlated with induction of HPV-16–specific immunity. Methods Immunogenicity and efficacy of a synthetic long-peptide vaccine in women with HPV-16–positive, high-grade vulvar intraepithelial neoplasia investigated 20 women with HPV-16–positive, grade 3 vulvar ... 3 or 4 times with mix of long peptides from HPV-16 viral oncoproteins E6 and E7 in incomplete Freund's adjuvant End points were clinical and HPV-16–specific T-cell responses Results Most common adverse events were local swelling in 100% of patients and fever in ... confidence interval [CI], 36 to 81) had clinical responses and reported relief of symptoms 5 women had complete regression of lesions, and HPV-16 was no longer detectable in 4 of them At 12 months of follow-up, 15 of 19 patients had clinical responses (79%; 95% CI, 54 to 94), with [more...]

HPV: Past, present, and in practice: The Omnia CME Journal
The Journal of Family Practice, 11/02/2009

Wright Jr TC et al. – This supplement addresses some important issues regarding human papillomavirus (HPV) and its effect on women. Even though most clinicians have a general understanding of the natural history of HPV and HPV DNA ... testing, many are using HPV DNA testing inappropriately. In addition, the knowledge base on HPV keeps expanding with well–validated, molecular tests that determine which women are infected with highrisk types of HPV. More news is available on a highly effective vaccine that prevents infection ... high–risk types of HPV—HPV 16 and 18. This volume of The Omnia CME Journal is titled “HPV: Past, present, and in practice.” Dr Thomas Wright’s article focuses on what we have recently learned about the natural history of HPV infections. The second is a reprint of a recent Clinical Update from ... Colposcopy and Cervical Pathology (ASCCP) on HPV assays. The third by Dr Barbara Levy is an article on implementing HPV vaccination in your office. All 3 are focused with the intent of providing you with key clinical points in an easy–to–digest format. [more...]

Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: A longitudinal study
European Journal of Cancer, 10/15/2009

grade CIN in young women, after controlling for cervical HPV infection. Methods Longitudinal analysis 1485 women aged 15–19 y 1075 HPV-negative and cytologically normal at recruitment 410 HPV-positive, cytologically abnormal or both Women re ... increased risk of high-grade CIN, after controlling for cervical HPV status In those HPV-negative and cytologically normal at recruitment, current smoking not significantly associated with risk of acquiring cervical HPV infection, after controlling for life-time number of partners and age ... length of time during which HPV could be detected [more...]

Signature sequence validation of human papillomavirus type 16 (HPV-16) in clinical specimens
Journal of Clinical Pathology, 11/10/2009

Lee SH et al. – DNA sequence analysis may be used for differential genotyping of HPV–16, HPV–31 and HPV–33 in clinical specimens. However, selection of the signature sequence for BLAST algorithms is crucial to distinguish certain HPV&ndash ... variants from other closely related HPV genotypes. [more...]

Human papillomavirus vaccination in survivors of childhood cancer
Cancer, 10/12/2009

is now available to prevent human papillomavirus (HPV), the most common sexually transmitted infection and the cause of cervical cancer, which is the second most common cancer among women worldwide. The purpose of this article was to describe the HPV vaccine and its usefulness in the survivorship ... cancer survivors as being at increased risk for HPV complications, identify factors associated with HPV vaccination, and discuss the utilization of these predictors in designing strategies to promote adherence to HPV vaccination recommendations within the survivorship context. [more...]

Human papillomavirus infection in Beijing, People's Republic of China: a population-based study
British Journal of Cancer, 10/01/2009

Zhao R et al. – HPV 16, HPV 58 and HPV 33 were the most prevalent HPV types in Beijing, indicating the potential for the prophylactic HPV 16/18 vaccine in China. [more...]

Human papillomavirus (HPV) infection in heterosexual South African men attending sexual health services: associations between HPV and HIV serostatus
Sexually Transmitted Infections, 11/09/2009

Muller EE et al. – Infections with HPV were prevalent among sexually active heterosexual men attending the men’s sexual health clinic ... between HIV co–infection and multiple HPV infections. Further population–based studies on the prevalence of HPV genotypes are required to determine if men should be included in any future national HPV vaccination programme in South Africa. [more...]