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Ethical challenges in paediatric clinical trials in multiple sclerosis Therapeutic Advances in Neurological Disorders, 06/08/2012
Tenembaum SN – There are ethical issues as well as issues related to feasibility that must be borne in mind when planning investigation trials for new pharmacological agents in the paediatric population, including immunological maturity, key period of exposure to numerous community–acquired infections, neurodevelopmental factors, in addition to short–term and long–term age–related toxicities.
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