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Humoral Antibody Response After Receipt of Inactivated Seasonal Influenza Vaccinations One Year Apart in Children
The Pediatric Infectious Disease Journal, 08/31/2012
Ng S et al. – Results from study suggest that humoral antibody response to TIV may be lower in children receiving repeated vaccination, but receipt of TIV induced seroprotection in most subjects. These study was underpowered to explore whether differences in immunogenicity translated to differences in vaccine efficacy.
Methods
- In a randomized controlled trial, they administered seasonal trivalent inactivated influenza vaccine (TIV) or placebo to 64 children 6–15 years of age in two consecutive years and explored their humoral antibody responses.
Results
- Receipt of TIV in the first year was associated with lower antibody titer rises in the second year to seasonal influenza A(H1N1) and A(H3N2) strains for which the vaccine strains remained unchanged.
- Antibody response to a different influenza B strain in the second year was unaffected by receipt of TIV in the first year.
- Children who received TIV in both years showed higher antibody titers against pandemic A(H1N1) which was not included in either TIV.
