Effects of Abeta1-42 on the current of KATP channels in cultured cholinergic neurons
Neurological Research, 08/17/2012
Tan S et al. – It is concluded that Abeta1–42 inhibits the openings of the KATP channels, while this inhibitory action can be removed by pretreatment with Diazoxide. It is indicated that the opening of KATP channels may play a potential neuroprotective role in antineurotoxicity of Abeta1–42, and the application of Diazoxide in small dose may be helpful in the treatment of Abeta1–42 neurotoxicity.