Prediction of metabolic syndrome among postmenopausal Ghanaian women using obesity and atherogenic markers Full Text
Lipids in Health and Disease, 08/20/2012
Arthur FKN et al. – The presence of metabolic syndrome among Ghanaian postmenopausal women can be predicted using WC, WHR, TG/HDL–C and HDL–C/TC.Methods
- Two hundred and fifty (250) Ghanaian subjects were involved in the study with one hundred and forty–three (143) being premenopausal women and one hundred and seven (107) postmenopausal women.
- The influence of traditional metabolic risk factors including high blood pressure, dyslipidemia and glucose intolerance on obesity and atherogenic indices i.e. body mass index (BMI), waist circumference (WC), waist–to–hip ratio (WHR), Waist–to–thigh ratio (WTR), waist–to–height ratio (WHtR), high density lipoprotein cholesterol to total cholesterol ratio (HDL–C/TC), high density lipoprotein cholesterol to low density lipoprotein ratio (HDL–C/LDL–C) and triglyceride to high density lipoprotein cholesterol ratio (TG/HDL–C) were identified according to the Harmonization (H_MS) criterion.
- The most significant anthropometric marker that significantly influence metabolic risk factors among the pre– and postmenopausal women was waist–to–hip ratio (premenopausal: p– 0.004, 0.026 and 0.002 for systolic blood pressure (SBP), fasting blood glucose (FBG) and HDL–C; postmenopausal: p–0.012, 0.048, 0.007 and 0.0061 for diastolic blood pressure (DBP), FBG, triglyceride (TG) and high density lipoprotein cholesterol (HDL–C) respectively).
- Using the receiver operating characteristic (ROC) analysis, the area under the curve for WC, WHR, TG/HDL–C and HDL–C/TC among postmenopausal women were estimated at 0.6, 0.6, 0.8 and 0.8 respectively.
- The appropriate cut–off values for WC, WHR, TG/HDL–C and HDL–C/TC that predicted the presence of metabolic syndrome were 80.5 cm, 0.84, 0.61 and 0.34 respectively.