Smartest Doc
Platelet rich plasma therapy: future or trend Full Text
Arthritis Research & Therapy, 08/09/2012
Dhillon RS et al. – Platelet–rich plasma (PRP) has found application in diverse surgical fields to enhance bone and soft–tissue healing by placing supra physiological concentrations of autologous platelets at the site of tissue damage. The relative ease of preparation, applicability in the clinic setting, favorable safety profile and possible beneficial outcome, makes PRP a promising therapeutic approach for future regenerative treatments.
- The platelets contain alpha granules that are rich in several growth factors such as platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-beta), insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), which play key roles in tissue repair mechanisms.
- PRP has found application in diverse surgical fields to enhance bone and soft-tissue healing by placing supra physiological concentrations of autologous platelets at the site of tissue damage.
- The relative ease of preparation, applicability in the clinic setting, favorable safety profile and possible beneficial outcome, makes PRP a promising therapeutic approach for future regenerative treatments.
- However, there is a large knowledge gap in the understanding of the PRP's mechanism of action, which has raised skepticism regarding its potential efficacy and use.
