Oxidative stress markers are associated to vascular recurrence in non-cardioembolic stroke patients non-treated with statins Full Text
BMC Neurology, 08/09/2012
Brea D et al. – Specific oxidative stress markers were found to be markers of atherosclerosis plaque types and vascular recurrence in non–statins treated patients at admission.Results
- Patients who suffered vascular recurrence or vascular–origin death had higher levels of 8–OHDG (40.06+/–24.70vs33.11+/–15.18;p=0.003).
- Authors also found associations between vascular recurrence or vascular origin death and Cu/ZnSOD (OR,1.02; 95%CI,1.00–1.03;p=0.0001) and 8–OHDG (OR,1.12;95%CI,1.08–1.16;p<0.0001) in a subgroup of 333 patients that were not in treatment with statins on admission.
- They also found associations between 8–OHDG and intima media thickness (IMT) (OR,1.13;95%CI,1.09–1.16;p<0.0001), presence of ipsilatieral stenosis[greater than or equal to]50% (OR,1.03;95%CI1.00–1.05;p=0.007) and other atherosclerotic plaque characteristics.