A case of Epstein-Barr virus-related lymphadenopathy mimicking the clinical features of IgG4-related disease
Modern Rheumatology, 08/03/2012
Wada Y et al. – A 72–year–old woman presented with a history of asthma attacks, systemic lymphadenopathy, hypergammaglobulinemia, proteinuria, and an elevated level of serum immunoglobulin G4 (IgG4), leading to a possible diagnosis of IgG4–related disease IgG4–RD based on current comprehensive diagnostic criteria. However, a percutaneous kidney biopsy specimen showed mild mesangial proliferative glomerulonephritis with focal membranous transformation, and there was no interstitial lesion or lymphocyte infiltration. Cervical lymph node biopsy demonstrated follicular hyperplasia associated with prominent lymphoplasmacytic infiltration in the interfollicular area. This case illustrates the diversity of conditions associated with elevated levels of serum IgG4 and the necessity for tissue biopsy when diagnosing IgG4–RD.