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Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
International Journal of Cancer, 07/27/2012
Frazzi R et al. – The classical HL–affected lymph nodes show a strong positivity of the diagnostic Hodgkin Reed–Sternberg cells. Notably, both the HL–derived cell lines and the Hodgkin Reed–Sternberg cells of the affected lymph nodes derive from germinal center–derived B cells. The study of SIRT1 distribution and expression on a larger number of biopsies might disclose a novel role for this histone/protein deacetylase as therapeutic target.
