Decelerated Early Growth in Infants of Overweight and Obese Mothers
The Journal of Pediatrics, 07/26/2012
Ode KL et al. – Maternal overweight/obesity is associated with early deceleration in linear growth and adipose tissue accrual; replication of these findings is needed.Methods
- Prospective cohort study performed at a university hospital/surrounding community.
- Ninety-seven nondiabetic mothers with singleton, term, healthy infants completed study visits at 2 weeks and 3 months of age.
- Before pregnancy, 59 mothers were normal weight, 18 were overweight, and 20 were obese. Infant anthropometrics and body composition via air-displacement plethysmography were measured. Infant feeding information and maternal prepregnancy weight were self-reported.
- Additional data were obtained via self-report and the medical record.
- Main outcome measures were change in weight, length, fat-free mass, and fat mass from 2 weeks to 3 months of age.
- Analysis was done via multivariate linear regression.
- At 2 weeks, anthropometrics and body composition did not differ across maternal body mass index groups.
- At 3 months, infants of overweight or obese mothers had gained less weight (P = .02), grew less in length (P = .01), and gained less fat mass (P = .01).
- Adjustment for breastfeeding status and regression to the mean via conditional change variables did not alter the results.
- The results were not altered after adjusting for maternal glucose values from a 50-g glucose challenge and for maternal smoking in a subset including 80% of the women.