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Fetal evaluation of the modified-myocardial performance index in pregnancies complicated by diabetes
Prenatal Diagnosis,
Clinical Article
Figueroa H et al. – In fetuses of diabetes (DM) mothers, evaluation of the Mod–Modified myocardial performance (MPI) identifies those with worse maternal disease and large fetal size
Methods- Modified myocardial performance index was measured in fetuses of patients with diabetes (DM) between 30 and 40 weeks of gestation.
- The isovolumetric contraction time, isovolumetric relaxation time and ejection time were measured. Mod–MPI was calculated as (isovolumetric contraction time+isovolumetric relaxation time)/ejection time.
- Results were analyzed by using one–way analysis of variance (post hoc Bonferroni correction), Chi–square and Student's test.
- Modified myocardial performance index values of fetuses from DM mothers were significantly higher than controls (0.43 vs 0.37, P<0.0001), and it was not different between gestational versus pregestational DM (0.42 vs 0.45, P=0.18).
- Mod–MPI was also higher in the presence of polyhydramnios (0.49 vs 0.41, P<0.0001), insulin use (0.46 vs 0.40, P<0.05), and large for gestational age fetuses (0.49 vs 0.40, P<0.0001).
- There were no significant differences in Mod–MPI between newborns with versus without neonatal complications such as hypoglycemia or polycythemia.
