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The independent relationship between creatinine clearance, microalbuminuria and circadian blood pressure levels in newly diagnosed essential hypertensive and type 2 diabetic patients
Journal of Diabetes and its Complications, 07/17/2012
Clinical Article
Afsar B et al. – Ambulatory blood pressure measurement (ABPM) measurements were highest in patients with both decreased glomerular filtration rate (GFR) and microalbuminuria (MA), whereas they are lowest in patients with normal GFR and normal UAE.
Methods- Medical history, physical examination, laboratory analysis and ambulatory blood pressure measurements (ABPMs) were analyzed.
- 24–h urine specimens were collected to measure creatinine clearance and albumin excretion.
- In total 216 patients were included which were divided into 4 groups: group 1 composed of 90 patients with normal GFR and without microalbuminuria (MA), group 2 composed of 50 patients with normal GFR and with MA, group 3 composed of 36 patients with decreased GFR and without MA and group 4 composed of 40 patients with both decreased GFR and MA.
- The ratio of dippers vs. non dippers was not different between group 1, group 2 and group 3 patients.
- However ratio of dippers was higher in group 1 when compared to group 4 (P: 0.003) and group 4 patients have an odds of 7.678 (CI: 1.657–35.576, P: 0.009) for non–dapping status when compared to patients in group 1.
