High-density lipoprotein cholesterol and the risk of nephropathy in type 2 diabetic patients
Nutrition, Metabolism & Cardiovascular Diseases,
Chang YH et al. – This study demonstrated for the first time that type 2 diabetic patients under a standard disease management program who have a stable and a higher mean HDL–C level were associated with a lower risk of development of diabetic nephropathy (DN).Methods
- A total of 864 patients who had participated in a comprehensive diabetic care program for at least for 3 years were studied.
- Patients were stratified into progressor (n = 180) and non–progressor groups (n = 684) according to the status of progression of DN during the follow–up period.
- By Cox regression analysis, a higher mean HDL–C level was observed to be a protective factor against the progression of DN [hazard ratio (95% CI): 0.971(0.953–0.989), P = 0.002] and a higher HDL–C variation was found to be associated with a higher risk [hazard ratio (95% CI): 1.177(1.032–1.341), P = 0.015] of DN progression.
- By the Kaplan–Meier survival curve, patients with a higher HDL–C level and lower HDL–C variability were found to have the lowest risk of development of nephropathy.