Revisiting regulatory T cells in type 1 diabetes
Current Opinion in Endocrinology, Diabetes and Obesity, 07/17/2012
Zhang Y et al. – The methylation status of the FOXP3 locus provides a means to re–examine Regulatory T cells (Treg) in autoimmune disease. nTreg and iTreg recognize different self–antigens. Shaping of Treg by the cytokine milieu has implications for the application of Treg cell–based immune therapies.