Role of intramyocelluar lipids in human health
Trends in Endocrinology and Metabolism, 06/22/2012
Coen PM et al. – This article reviews current knowledge of Intramyocellular lipid (IMCL)–mediated insulin resistance (IR) and important areas of investigation, including myocellular lipid transport and lipid droplet proteins. Several crucial questions remain unanswered, such as the identity of specific ceramide and diacylglycerol species that mediate IR in human muscle and their subcellular location. Quantitative lipidomics and proteomics of targeted subcellular organelles will help to better define the mechanisms underlying pathological IMCL accumulation and IR.