Bronchial reactivity and Fractional Exhaled NO in Crohns Disease in the era of immunomodulating treatment
Acta Pediatrica, 06/21/2012
Livnat G et al. – In series, bronchial hyper–responsiveness (BHR) is less frequent than previously described in children with CD. They hypothesize that finding could result from immunomodulating treatments or lower disease activity.Methods
- Consecutive children with CD were referred to the Pediatric Pulmonary Unit. Each patient completed a questionnaire, followed by spirometry, Methacholine challenge test (MCT), and determination of FeNO.
- The control group included patients evaluated for functional cough who had negative MCT.
- Twenty-three children and young adults with CD were compared to 24 healthy controls.
- 20/23 patients received immunomodulating treatment.
- Forced expiratory volume in 1 second (FEV1) was significantly lower prior to and at the end of the MCT in the CD group compared with the control group.
- Bronchial hyper-responsiveness was observed in 30.4% of patients with CD.