Caffeinated and decaffeinated coffee and tea intakes and risk of colorectal cancer in a large prospective study
American Journal of Clinical Nutrition, 06/26/2012
Sinha R et al. – In this large US cohort, coffee was inversely associated with colon cancer, particularly proximal tumors. Additional investigations of coffee intake and its components in the prevention of colorectal cancer by subsites are warranted.Methods
- The NIH-AARP Diet and Health Study included 489,706 men and women who completed a baseline (1995–1996) self-administered questionnaire of demographics, diet, and lifestyle.
- Over a median of 10.5 y of follow-up, they identified 2863 proximal colon, 1993 distal colon, and 1874 rectal cancers
- Multivariable HRs and 95% CIs were estimated by using Cox regression.
- Approximately 16% of participants drank >4 cups coffee/d. Compared with nondrinkers, drinkers of 4–5 cups coffee/d (HR: 0.85; 95% CI: 0.75, 0.96) and >6 cups coffee/d (HR: 0.74; 95% CI: 0.61, 0.89; P-trend < 0.001) had a lower risk of colon cancer, particularly of proximal tumors
- Results were similar to those overall for drinkers of predominantly caffeinated coffee.
- Although individual HRs were not significant, there was a significant P-trend for both colon and rectal cancers for people who drank predominantly decaffeinated coffee.