Determination of Bone Architecture and Strength in Men and Women with Stage 5 Chronic Kidney Disease
Seminars in Dialysis, 06/15/2012
West SL et al. – Dual energy X–ray absorptiometry does not capture bone microarchitecture and cannot differentiate between cortical and trabecular bone. Some, but not all studies, that measure cortical and trabecular bone by peripheral quantitative computed tomography in stage 5D chronic kidney disease (CKD), demonstrate a preferential decrease in cortical bone; however, these studies are limited by small sample sizes and cross–sectional study design. No studies have reported on longitudinal relationships between bone architecture, strength, and incident fractures in patients with stage 5D CKD.