Corpus Callosum Atrophy – A Simple Predictor of Multiple Sclerosis Progression: A Longitudinal 9-Year Study
European Neurology, 06/26/2012
Vaneckova M et al. – Corpus callosum atrophy is a simple and accurate predictor of future disability accumulation and is feasible for routine clinical practice.Methods
- In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after treatment initiation.
- Non-parametric and multiple regression models were built to identify the most reliable predictors of disability and of its changes over 9 years.
- Corpus callosum atrophy during the first year of treatment was the best predictor of disability (r=-0.56) and of its increase at 9 years (r=0.65).
- Corpus callosum atrophy of at least 2% predicted increase in disability with 93% sensitivity and 73% specificity (odds ratio = 35).