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Association between the chemokine receptor 5 delta32 polymorphism and rheumatoid arthritis: a meta-analysis
Modern Rheumatology, 05/31/2012
Evidence Based Medicine
Lee YH et al. – This meta–analysis demonstrates that the chemokine receptor 5 delta32 (CCR5–Δ32) polymorphism may confer susceptibility to rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in Europeans, and suggests that the CCR5–Δ32 allele protects against the development of RA and JIA.
Methods- Meta–analysis was conducted on associations between the CCR5–Δ32 polymorphism and RA and JIA using
- (1) allele contrast
- (2) the recessive
- (3) the dominant
- (4) the additive models.
- Eleven population comparisons based on the data obtained from nine studies involving 13,412 subjects (RA 3,848, controls 4,095; JIA 1,599, controls 3,870) were considered.
- In all study subjects, meta–analysis showed a significant negative association between RA and the CCR5–Δ32 allele (OR = 0.771, 95 % CI = 0.694–0.866, p = 6.5 × 10–7).
- Stratification by ethnicity indicated a significant association between the CCR5–Δ32 allele and RA in Europeans (OR = 0.8001, 95 % CI = 0.709–0.904, p = 3.2 × 10–5).
- Meta–analysis showed associations between the CCR5–Δ32 allele and JIA in Europeans and oligoarticular type (OR = 0.797, 95 % CI = 0.690–0.921, p = 0.002; OR = 0.475, 95 % CI = 0.352–0.693, p = 9.5 × 10–8).
