Efficacy and safety of oral and parenteral methotrexate therapy in children with juvenile idiopathic arthritis. An observational study with patients of the German Methotrexate Registry
Arthritis Care & Research ,  Clinical Article

Klein A et al. – Inthis retrospective analysis parenteral MTX was not superior to oral administration regarding efficacy and tolerability.

  • Inclusion criteria were diagnosis of JIA, MTX treatment for at least 6 months, a consistent route of administration of MTX and no previous or concomitant treatment with biologics.
  • Efficacy was measured by PedACR criteria.
  • Primary outcome was efficacy defined as the number of patients reaching PedACR 30 criteria after 6 months of treatment.
  • Secondary outcome criteria were the PedACR50 and 70 criteria at 6 and 12 months of treatment.
  • Analyses were performed with the intention to treat population.

  • Of the 411 eligible patients 259(63)%received oral and 152(37%)subcutaneous MTX.
  • In both patient groups a comparable weekly dosage of MTX(0.4 mg/kg vs. 0.42 mg/kg)was used, a comparable number of patients received concomitant steroids.
  • Primary outcome: In both treatment groups a comparably high number of patients showed a clinical response according to the PedACR 30 score after 6 months of treatment(73% vs. 72%, p=0.87). 22% of patients with oral and 27% with subcutaneous therapy had at least one documented adverse event.
  • Discontinuation of treatment was observed equally frequent in both groups while significantly more patients with subcutaneous application discontinued MTX because of adverse events(11% vs. 5%, p=0.02).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nursing

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nursing Articles

1 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Clinical Article

2 Vitamin D and sleep disorders Full Text Nature and Science of Sleep, August 13, 2014    Free full text    Clinical Article

3 Blood pressure in relation to coffee and caffeine consumption Current Hypertension Reports, August 8, 2014    Review Article

4 Metformin in chronic kidney disease: Time for a rethink Peritoneal Dialysis International, July 9, 2014    Clinical Article

5 Suffering from constipation? Self-acupressure can help UCLA Health System, November 19, 2014

6 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

7 UAB plans clinical trial for repurposed drug shown to reverse diabetes UAB Medicine, November 12, 2014

8 Long-term associations of nut consumption with body weight and obesity American Journal of Clinical Nutrition, June 23, 2014    Clinical Article

9 Decreased ability to identify odors can predict death The University of Chicago Medical Center News, October 3, 2014

10 Chocolate intake and diabetes risk Clinical Nutrition, July 21, 2014    Clinical Article

11 Vitamin D and the risk of dementia and Alzheimer's disease Neurology®, August 27, 2014    Clinical Article

12 Vitamin D and melanoma and non-melanoma skin cancer risk and prognosis: A comprehensive review and meta-analysis European Journal of Cancer, August 7, 2014    Review Article

13 Study identifies best way to treat neck pain Johns Hopkins Medicine, October 24, 2014

14 Yogurt and weight management American Journal of Clinical Nutrition, April 3, 2014    Review Article

15 Proton pump inhibitors decrease diversity in gut microbiome, increase risk for complications Mayo Clinic, November 25, 2014

16 'Tis the season to indulge in walnuts UC Davis Health System, November 17, 2014

17 Fish consumption and risk of gastrointestinal cancers: A meta-analysis of cohort studies Full Text World Journal of Gastroenterology, November 17, 2014    Free full text    Evidence Based Medicine

18 Associations of sugar and artificially sweetened soda and chronic kidney disease: A systematic review and meta-analysis Nephrology, September 24, 2014    Evidence Based Medicine    Review Article

19 Eating habits, body fat related to differences in brain chemistry Full Text NIH News, September 10, 2014    Free full text

20 Dairy product consumption and gastric cancer risk: A meta-analysis Full Text World Journal of Gastroenterology, November 14, 2014    Free full text    Evidence Based Medicine

Indexed Journals in Nursing: Journal of Advanced Nursing, Journal of Clinical Nursing, Nurse Education In Practicemore