The role of prior corticosteroids on the clinical course of Stevens-Johnson syndrome and toxic epidermal necrolysis: A case-control analysis of patients selected from the multi-national EuroSCAR and RegiSCAR studies.
British Journal of Dermatology, 06/01/2012
Lee HY et al. – The prior use of corticosteroids prolonged the period of disease progression without influencing the disease severity or mortality. In addition, when Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is preceded by a single high–risk drug, the latency between the drug intake and the onset of SJS/TEN may also be increased. These findings suggest that corticosteroids have some mild impact on the course of SJS/TEN and further studies are required to clarify any potential therapeutic effects.