The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells
Endocrine-Related Cancer, 05/31/2012
De Martino MC et al. – The current study demonstrates that mTOR inhibitors inhibit the proliferation and cortisol production in adrenocortical carcinoma (ACC) cells. Different ACC cells have different sensitivity to the mTOR inhibitors. mTOR could be a target for the treatment of human ACCs, but variable responses might be expected. In selected cases of ACC, the combined targeting of mTOR and IGF2 could have greater effects than mTOR inhibitors alone.