Bone Marrow Cell Therapies for Endothelial Repair and Their Relevance to Kidney Disease
Seminars in Nephrology, 05/23/2012
Yuen DA et al. – Endothelial injury is a characteristic finding in chronic kidney disease and is associated with both markedly increased cardiovascular risk and chronic kidney disease progression. The past decade has seen a remarkable surge of interest in the role of bone marrow–derived cells for the protection, repair, and regeneration of injured endothelium. In particular, despite controversies regarding their mechanisms of action, endothelial progenitor cells have garnered considerable attention, with multiple reports suggesting that these cells exhibit remarkable pro–angiogenic effects.