The Endothelium in Diabetic Nephropathy
Seminars in Nephrology, 05/23/2012
Advani A et al. – The hypoxic milieu that follows the microvascular rarefaction provides a potent stimulus for fibrogenesis, leading to the glomerulosclerosis and tubulointerstitial fibrosis that characterize advanced diabetic kidney disease. Such advances likely will lead not only to improved tissue oxygenation and reduced fibrosis, but also to improved long–term renal function.