PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility
The Journal of Sexual Medicine, 05/23/2012
Matos G et al. – Evidence suggests an influence of phosphodiesterase type 5 inhibitor (PDEI–5) on seizure susceptibility in humans. In addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI–5 on seizure susceptibility.