Parkinsons disease and immune system: is the culprit LRRKing in the periphery
Journal of Neuroinflammation, 05/21/2012
Greggio E et al. – Leucine–rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson's disease; Crohn's disease; and leprosy. Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is suggested by its high expression in immune cells and tissues, its up–regulation by interferon gamma, and its function as negative regulator of the immune response transcription factor NFAT1.